Melorheostosis and Marijuana Information: Treat Melorheostosis With Cannabis

Melorheostosis is a rare skeletal abnormality. It causes a lesion of bone to become overly thick and dense. The skin and soft tissues surrounding the bone lesion also harden. Melorheostosis tends to be limited to one extremity.  Melorheostosis can cause pain, limit range of movement (if a joint is involved), or stunt the growth of an affected extremity.

Melorheostosis is thought to occur during fetal development, however signs and symptoms tend not to present until later childhood or early adulthood.

Signs and symptoms of melorheostosis include irregular bone growth, including cortical thickening and “dripping candle wax” appearance on x-ray imaging; unequal length of limbs; joint swelling and fusion; soft tissue abnormalities, including tendon and ligament shortening, absent or abnormal muscles, subcutaneous calcification, and contractures resulting in malformed or immobilized joints; range of motion limitations; pain and stiffness; limb swelling (edema) and vascular abnormalities. Less commonly, but severe, the bone lesions may compress the surrounding nerves.


Melorheostosis is a sporadic and progressive condition, and is not inherited.

Clinical Information Related to Melorheostosis and Medical Marijuana

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