What drugs should not be taken with CBD? There are a lot of studies about blood thinners mood helpers pain medications Coumadin is one – CBD could block the metabolism of these drugs, causing them to remain in a higher concentration and be more active which can become more toxic and cause complications. My aunt went through this with her blood thinners and so she had to stop taking CBD and Medical Marijuana all together. Talk to your doctor to see what if there is a drug to drug interaction and if they are to avoid any complications in trying CBD and Cannabis with your medications.