Epidermolysis Bullosa and Marijuana Information: Treat EB With Cannabis

Normal human skin has two layers, the epidermis, which is the outer part, and the dermis, or the inner part. Normally, there are protein anchors between the layers, made of collagen, and they prevent the two layers from shearing, or moving independently from one another.

People with Epidermolysis Bullosa (EB) do not have these protein anchors, so when there is any friction on the skin, the two layers rub against each other and separate, resulting in painful sores and blisters. The blistering can also occur in the inner mucous membranes, such as the mouth and esophagus. This makes it almost impossible to eat solids.

Epidermolysis Bullosa can result from a genetic mutation in one of 18 genes. These mutations, or errors in the genetic code, do not allow the body to either produce an essential protein or produce a working form of the protein thus resulting in extremely fragile skin. – EB has three major forms and at least 16 subtypes. Each type has different genetic and symptomatic variations, but all forms share the common symptom of fragile skin that blisters and tars from even the slightest friction or trauma.

Clinical Information Related to Epidermolysis Bullosa and Medical Marijuana

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