Darier Disease and Marijuana Information: Treat Dariers With Cannabis

Darier disease (keratosis follicularis) is an inherited disorder affecting the outermost layer of the skin, the epidermis, which thickens around the hair follicles. The disease also manifests as impaired cell adhesion, meaning that the cells do not bind to each other as they should, and as a result the skin is frail. 

Symptoms start with rough pimples (papules) appearing in the outermost layer of the skin, especially around the hair follicles. The papules develop into a brownish rash, especially on the face, chest and back. Over time, the papules grow together, forming thick plaques with a moist surface. These plaques are susceptible to bacterial infections or herpes virus. Severe cystic acne may also occur. In some individuals the skin changes are limited, affecting for example the forehead and the chest, but in other cases large areas of the trunk, the lower legs, the neck, armpits and groin are affected. 

The severity of the disease may also vary over time. Heat and humidity tend to exacerbate the rash. UV light and minor skin injuries may also worsen the condition. Almost everyone with the disease has small, hard pits on the palms of the hands and soles of the feet, and the nails are usually cracked.

Clinical Information Related to Darier Disease and Medical Marijuana

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